ea0022s25.1 | Non-classical responses to hormones | ECE2010
Castoria Gabriella
, Migliaccio Antimo
, Giovannelli Pia
, Giraldi Tiziana
, Auricchio Ferdinando
Androgen stimulation triggers rapid activation of signaling pathways in target cells. The initial event is a rapid interaction of classical androgen receptor (AR) with Src. Activation of these pathways fosters cell cycle, prevents apoptosis and leads to cytoskeleton changes in reproductive as well as non-reproductive cells. The role of Src activation in the androgen proliferative action has been recently corroborated by findings showing that specific interference in Src/AR ass...